Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia.

@article{Rajakumar2012TranscriptionallyAS,
  title={Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia.},
  author={Augustine Rajakumar and A. Cerdeira and Sarosh Rana and Zsuzsanna K Zsengeller and Lia R. Edmunds and Arundhathi Jeyabalan and Carl A. Hubel and Isaac E Stillman and Samir M Parikh and S Ananth Karumanchi},
  journal={Hypertension},
  year={2012},
  volume={59 2},
  pages={256-64}
}
The cardinal manifestations of the pregnancy-specific disorder preeclampsia, new-onset hypertension, and proteinuria that resolve with placental delivery have been linked to an extracellular protein made by the placenta, soluble fms-like tyrosine kinase 1 (sFlt1), that injures the maternal vasculature. However, the mechanisms by which sFlt1, which is heavily matrix bound, gain access to the systemic circulation remain unclear. Here we report that the preeclamptic placenta's outermost layer, the… CONTINUE READING