Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

@article{Aymard2014TranscriptionallyAC,
  title={Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks},
  author={François Aymard and B{\'e}atrix Bugler and Christine Katrin Schmidt and Emmanuelle Guillou and Pierre Caron and Sebastien Briois and Jason S. Iacovoni and Virginie Daburon and Kyle M Miller and Stephen P. Jackson and Ga{\"e}lle Legube},
  journal={Nature Structural &Molecular Biology},
  year={2014},
  volume={21},
  pages={366-374}
}
Although both homologous recombination (HR) and nonhomologous end joining can repair DNA double-strand breaks (DSBs), the mechanisms by which one of these pathways is chosen over the other remain unclear. Here we show that transcriptionally active chromatin is preferentially repaired by HR. Using chromatin immunoprecipitation–sequencing (ChIP-seq) to analyze repair of multiple DSBs induced throughout the human genome, we identify an HR-prone subset of DSBs that recruit the HR protein RAD51… CONTINUE READING
Highly Cited
This paper has 140 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF)

Kriegsheim
2017
View 5 Excerpts
Highly Influenced

141 Citations

02040'14'15'16'17'18'19
Citations per Year
Semantic Scholar estimates that this publication has 141 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 58 references

A cell cycledependent regulatory circuit composed of 53 BP 1RIF 1 and BRCA 1CtIP controls DNA repair pathway choice

C. Escribano-Díaz
Mol . Cell • 2013