Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

  title={Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks},
  author={François Aymard and B{\'e}atrix Bugler and Christine Katrin Schmidt and Emmanuelle Guillou and Pierre Caron and Sebastien Briois and Jason S. Iacovoni and Virginie Daburon and Kyle M Miller and Stephen P. Jackson and Ga{\"e}lle Legube},
  journal={Nature Structural &Molecular Biology},
Although both homologous recombination (HR) and nonhomologous end joining can repair DNA double-strand breaks (DSBs), the mechanisms by which one of these pathways is chosen over the other remain unclear. Here we show that transcriptionally active chromatin is preferentially repaired by HR. Using chromatin immunoprecipitation–sequencing (ChIP-seq) to analyze repair of multiple DSBs induced throughout the human genome, we identify an HR-prone subset of DSBs that recruit the HR protein RAD51… CONTINUE READING
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