Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.

@article{Huang2009TranscriptionalUO,
  title={Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.},
  author={Wen-jie Huang and Li-min Xia and Fan Zhu and Bo Huang and Chun Jiang Zhou and Hui-fen Zhu and Bo Wang and Bingguang Chen and Ping Lei and Guan-xin Shen},
  journal={International journal of cancer},
  year={2009},
  volume={124 2},
  pages={298-305}
}
Heat shock protein 70-2 (HSP70-2) can be expressed by cancer cells and act as an important regulator of cancer cell growth and survival. Here, we show the molecular mechanisms by which hypoxia regulate HSP70-2 expression in cancer cells. When cells were subjected to hypoxia (1% O2), the expression of HSP70-2 had a significant increase in cancer cells. Such increase was due to the direct binding of hypoxia-inducible factor to hypoxia-responsive elements (HREs) in the HSP70-2 promoter. By… CONTINUE READING

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