Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter.

@article{Kerry1996TranscriptionalSB,
  title={Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter.},
  author={D M Kerry and Prem P. Dwivedi and Christopher N Hahn and Howard A. Morris and John L Omdahl and Brian K May},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 47},
  pages={29715-21}
}
Transcription of the CYP24 gene is induced by 1,25-(OH)2D3 through a vitamin D receptor-dependent process. The functional activities of three possible vitamin D response elements (VDREs), located on the antisense strand of the rat CYP24 promoter, were investigated by transient expression of native and mutant promoter constructs in COS-1, JTC-12, and ROS 17/2.8 cells. A putative VDRE with a half-site spacing of 6 base pairs at -249/-232 (VDRE-3) did not contribute to 1,25-(OH)2D3 induced… CONTINUE READING

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