Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.

@article{Mott2010TranscriptionalSO,
  title={Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.},
  author={Justin L Mott and Satoshi Kurita and Sophie C. Cazanave and Steven F. Bronk and Nathan W. Werneburg and Martin E Fernandez-Zapico},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={110 5},
  pages={
          1155-64
        }
}
MicroRNAs regulate pathways contributing to oncogenesis, and thus the mechanisms causing dysregulation of microRNA expression in cancer are of significant interest. Mature mir-29b levels are decreased in malignant cells, and this alteration promotes the malignant phenotype, including apoptosis resistance. However, the mechanism responsible for mir-29b suppression is unknown. Here, we examined mir-29 expression from chromosome 7q32 using cholangiocarcinoma cells as a model for mir-29b… CONTINUE READING
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