Transcriptional suppression of human microsomal triglyceride transfer protein by hypolipidemic insulin sensitizers.

@article{Sheena2005TranscriptionalSO,
  title={Transcriptional suppression of human microsomal triglyceride transfer protein by hypolipidemic insulin sensitizers.},
  author={Vered Sheena and Rachel Hertz and Ina Berman and Janna Nousbeck and Jacob Bar-Tana},
  journal={Biochemical pharmacology},
  year={2005},
  volume={70 11},
  pages={
          1548-59
        }
}
Microsomal triglyceride transfer protein (MTP) catalyzes the assembly and secretion of liver triglyceride-rich lipoproteins. The human MTP (hMTP) promoter activity is reported here to be suppressed by HNF-4alpha ligand antagonists (e.g., Medica analogs) or by PPARgamma ligand agonists (e.g., thiazolidinediones), thus accounting for their hypolipidemic activity in humans. Suppression of liver hMTP by Medica analogs or by thiazolidinediones was mediated by the TAAA sequence that serves as non… CONTINUE READING