Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding.

@article{Zhang2011TranscriptionalSO,
  title={Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding.},
  author={Jidong Zhang and Xuesong Qian and Huan Ning and Christopher S. Eickhoff and Daniel F. Hoft and Jianguo Liu},
  journal={Journal of immunology},
  year={2011},
  volume={186 10},
  pages={5885-95}
}
Mycobacterium tuberculosis remains a major global challenge to human health care, and the mechanisms of how M. tuberculosis evades host immune surveillance to favor its survival are still largely unknown. In this study, we found that bacillus Calmette-Guérin (BCG) and viable M. tuberculosis as well as M. tuberculosis lysates could activate IL-27 expression in human and mouse macrophages by induction of p28 subunit transcription. However, in parallel with these effects, BCG and M. tuberculosis… CONTINUE READING

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