Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

  title={Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase},
  author={S. Imai and C. M. Armstrong and M. Kaeberlein and L. Guarente},
  • S. Imai, C. M. Armstrong, +1 author L. Guarente
  • Published 2000
  • Medicine, Biology
  • Nature
  • Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. Mutational studies indicate that lysine 16 in the amino-terminal tail of histone H4 and lysines 9, 14 and 18 in H3 are critically important in silencing, whereas lysines 5, 8 and 12 of H4 have more redundant functions. Lysines 9 and 14 of histone H3 and lysines 5, 8 and 16 of H4 are… CONTINUE READING
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