Transcriptional signatures of brain aging and Alzheimer’s disease: What are our rodent models telling us?

@article{Hargis2017TranscriptionalSO,
  title={Transcriptional signatures of brain aging and Alzheimer’s disease: What are our rodent models telling us?},
  author={Kendra E Hargis and Eric M. Blalock},
  journal={Behavioural Brain Research},
  year={2017},
  volume={322},
  pages={311-328}
}
Aging is the biggest risk factor for idiopathic Alzheimer's disease (AD). Recently, the National Institutes of Health released AD research recommendations that include: appreciating normal brain aging, expanding data-driven research, using open-access resources, and evaluating experimental reproducibility. Transcriptome data sets for aging and AD in humans and animal models are available in NIH-curated, publically accessible databases. However, little work has been done to test for concordance… CONTINUE READING
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