Transcriptional signatures for coupled predictions of stage II and III colorectal cancer metastasis and fluorouracil-based adjuvant chemotherapy benefit.

@article{Li2018TranscriptionalSF,
  title={Transcriptional signatures for coupled predictions of stage II and III colorectal cancer metastasis and fluorouracil-based adjuvant chemotherapy benefit.},
  author={Zhenjie Li and You -Hao Guo and Xianlong Wang and Hao Cai and Weicheng Zheng and Na Li and Xuekun Song and Lu Ao and Zheng Guo and Wenyuan Zhao},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2018},
  pages={
          fj201800222RRR
        }
}
The current study suggests that the identification of predictive signatures of fluorouracil (5-FU) response for stage II and III colorectal cancer (CRC) could be confounded by chemotherapy-irrelevant low relapse risk. Using the samples of patients with stage II and III CRC who were treated with curative surgery only, we identified a signature with which to predict chemotherapy-irrelevant relapse risk for patients after curative surgery. By applying this signature to the samples of patients with… CONTINUE READING