Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naïve patients

@article{Martnez2005TranscriptionalSO,
  title={Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naïve patients},
  author={N. Mart{\'i}nez and M. S{\'a}nchez-Beato and A. Carnero and V. Moneo and J. Tercero and I. Fern{\'a}ndez and M. Navarrete and J. Jimeno and M. Piris},
  journal={Molecular Cancer Therapeutics},
  year={2005},
  volume={4},
  pages={814 - 823}
}
Ecteinascidin 743 (ET-743; Yondelis, Trabectedin) is a marine anticancer agent that induces long-lasting objective remissions and tumor control in a subset of patients with pretreated/resistant soft-tissue sarcoma. Drug-induced tumor control is achievable in 22% of such patients, but there is no clear indication of the molecular features correlated with clinical sensitivity/resistance to ET-743. Nine low-passage, soft-tissue sarcoma cell lines, explanted from chemo-naïve patients with… Expand
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Extreme sensitivity to Yondelis® (Trabectedin, ET‐743) in low passaged sarcoma cell lines correlates with mutated p53
ET-743: a novel agent with activity in soft-tissue sarcomas
Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas
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Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.
Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743 in Cancer Cells
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