Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter.

@article{Gong1991TranscriptionalRO,
  title={Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter.},
  author={Qi Hai Gong and Joshua Stern and Ann Dean},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 5},
  pages={2558-66}
}
The epsilon-globin gene is the first of the human beta-like globin genes to be expressed during development. We have analyzed protein-DNA interactions in the epsilon-globin promoter region by DNase I footprinting and electrophoretic mobility shift experiments using nuclear extracts from K562 human erythroid cells and from nonerythroid HeLa cells. A restricted set of ubiquitous proteins, including Sp1, bound to regions of the promoter including the CACCC and CCAAT sites. Three interactions, at… CONTINUE READING

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