Transcriptional response of human umbilical vein endothelial cells to low doses of ionizing radiation.

@article{Lanza2005TranscriptionalRO,
  title={Transcriptional response of human umbilical vein endothelial cells to low doses of ionizing radiation.},
  author={Vincenzo Lanza and Valeria Pretazzoli and Gregorio Olivieri and Giuseppe Pascarella and Alessandro Panconesi and Rodolfo Negri},
  journal={Journal of radiation research},
  year={2005},
  volume={46 2},
  pages={265-76}
}
We used cDNA microarray hybridization technology to monitor the transcriptional response of Human Umbilical Vein Endothelial (HUVEC) cells to x-rays doses ranging from 2 to 200 cGy. An early time window from irradiation (4h) was selected in order to minimize the effects of the cell cycle blockage eventually induced at high doses of irradiation. Three different gene-clustering algorithms have been used to group the 4134 monitored ORF based on their transcriptional response in function of the… CONTINUE READING

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