Transcriptional response of human microglial cells to interferon-γ

  title={Transcriptional response of human microglial cells to interferon-γ},
  author={Robert Bryan Rock and Shuxian Hu and Anagha Deshpande and Shamaila Munir and Barbara J. May and Christopher A. Baker and Phillip K. Peterson and Vivek Kapur},
  journal={Genes and Immunity},
Microglia, the resident macrophages in the central nervous system (CNS), play a pivotal role in innate and adaptive immune responses in the brain. The immune functions of microglia are regulated by cytokines, including interferon (IFN)-γ, which is a major mediator of macrophage activation. We describe the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-γ treatment. The results show a change in the expression of 405 genes including transcriptionally induced… CONTINUE READING
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