Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11

@article{Sayama2002TranscriptionalRO,
  title={Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11},
  author={Koichi Sayama and Maximilian Diehn and Kentaro Matsuda and Carolina Lunderius and Mindy Tsai and S. Tam and David Botstein and Patrick O. Brown and Stephen J. Galli},
  journal={BMC Immunology},
  year={2002},
  volume={3},
  pages={5 - 5}
}
In asthma and other allergic disorders, the activation of mast cells by IgE and antigen induces the cells to release histamine and other mediators of inflammation, as well as to produce certain cytokines and chemokines. To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (FcεRI). One to two hours after FcεRI-dependent stimulation, more than 2,400… CONTINUE READING
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