Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection

  title={Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection},
  author={Jennifer D Cotter and Andrew Storfer and Robert B Page and Christopher K. Beachy and Stephen Randal Voss},
  journal={BMC Genomics},
  pages={493 - 493}
Very little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize gene expression responses of axolotls (Ambystoma mexicanum) to an emerging viral pathogen, Ambystoma tigrinum virus (ATV). At 0, 24, 72, and 144 hours post-infection, spleen and lung samples were removed for estimation of host mRNA abundance and viral load. A total of 158 up-regulated and 105 down-regulated genes… CONTINUE READING


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