Transcriptional repressor snail and metastasis in hepatocellular carcinoma.

  title={Transcriptional repressor snail and metastasis in hepatocellular carcinoma.},
  author={Dong Chen and Xuefeng Zheng and Xuelong Jiao and Yuan Gao and Kejun Zhang and Jun Liang},
  volume={59 117},
BACKGROUND/AIMS We aimed to elucidate the effect of Snail transcriptional factor on invasion and metastasis and related molecular mechanisms in HCC. METHODOLOGY Quantitative RT-PCR was performed to evaluate Snail, E-cadherin and MMP-2 mRNA expressions in HCC tissues from 47 patients as well as the expressions with metastases in these patients. Snail siRNA was transfected into the Snail-over expressing HCC cells and Snail cDNA was transfected into the less Snail-expressed HCC cells. A pseudo… CONTINUE READING
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