Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.

Abstract

Timely DNA replication across damaged DNA is critical for maintaining genomic integrity. Translesion DNA synthesis (TLS) allows bypass of DNA lesions using error-prone TLS polymerases. The E3 ligase RAD18 is necessary for proliferating cell nuclear antigen (PCNA) monoubiquitination and TLS polymerase recruitment; however, the regulatory steps upstream of… (More)
DOI: 10.1016/j.molcel.2014.02.017

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