Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

Abstract

T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of terminal B cell differentiation, was… (More)
DOI: 10.1038/ni1321

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