Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.

  title={Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.},
  author={Kellie A. Charles and Laurent P. Rivory and Sandie L Brown and Christopher Liddle and Stephen J. Clarke and Graham R. Robertson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 24},
PURPOSE Many chemotherapeutic drugs have an inherent lack of safety due to interindividual variability of hepatic cytochrome P450 (CYP) 3A4 drug metabolism. This reduction in CYP3A4 in cancer patients is possibly mediated by cytokines associated with tumor-derived inflammation. We sought to examine this link by using an explant sarcoma in a novel transgenic mouse model of human CYP3A4 regulation. EXPERIMENTAL DESIGN Engelbreth-Holm-Swarm sarcoma cells were injected into the hindlimb of… CONTINUE READING
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