Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53

@article{Park2015TranscriptionalRO,
  title={Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53},
  author={Eun Kyung Park and Jung Chang Lee and Jong Woo Park and So Young Bang and Sang Ah Yi and Bo Kyum Kim and Jae Hyun Park and Sang Hoon Kwon and Jeong Soo You and Suk Woo Nam and Eun Jung Cho and Jae Woong Han},
  journal={Cell Death and Disease},
  year={2015},
  volume={6},
  pages={e1964-}
}
Novel therapeutic strategies are needed to overcome cancer recurrence, metastasis, and resistance to chemo- and radiotherapy. Cancer stem cells (CSCs) are major contributors to the malignant transformation of cells due to their capacity for self-renewal. Although various CSC markers have been identified in several types of tumors, they are primarily used as cancer-prediction markers and for the isolation of CSC populations. CD133, one of the best-characterized CSC markers in distinct solid… CONTINUE READING