Transcriptional repression of C4 complement by hepatitis C virus proteins.

  title={Transcriptional repression of C4 complement by hepatitis C virus proteins.},
  author={Arup Banerjee and Budhaditya Mazumdar and Keith A Meyer and Adrian M Di Bisceglie and Ratna B Ray and Ranjit Ray},
  journal={Journal of virology},
  volume={85 9},
The fourth component of human complement (C4) plays an important role in innate immune function. C4 activity has been observed to be significantly lower in patients with chronic hepatitis C virus (HCV) infections, although the mechanism remains unknown. In this study, we have examined the mechanisms of C4 regulation by HCV. Liver biopsy specimens from patients with chronic HCV infections displayed significantly lower C4 mRNA levels than liver tissue samples from patients with unrelated liver… CONTINUE READING