Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

@article{Hoshino2006TranscriptionalRI,
  title={Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73},
  author={Masataka Hoshino and Mei-ling Qi and Natsue Yoshimura and Tomoyuki Miyashita and Kazuhiko Tagawa and Yo-ichi Wada and Yasushi Enokido and Shigeki Marubuchi and Phoebe Harjes and Nobutaka Arai and Kiyomitsu Oyanagi and Giovanni Blandino and Marius Sudol and Tina Rich and Ichiro Kanazawa and Erich E. Wanker and Minoru Saitoe and Hitoshi Okazawa},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={172},
  pages={589 - 604}
}
Transcriptional disturbance is implicated in the pathology of polyglutamine diseases, including Huntington's disease (HD). However, it is unknown whether transcriptional repression leads to neuronal death or what forms that death might take. We found transcriptional repression-induced atypical death (TRIAD) of neurons to be distinct from apoptosis, necrosis, or autophagy. The progression of TRIAD was extremely slow in comparison with other types of cell death. Gene expression profiling revealed… CONTINUE READING