Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes.

@article{VanderWielen2011TranscriptionalRI,
  title={Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes.},
  author={Bradley D. VanderWielen and Zhenyu Yuan and David R Friedmann and Rhett A. Kovall},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 17},
  pages={14892-902}
}
The Notch pathway is a conserved cell-to-cell signaling mechanism that mediates cell fate decisions in metazoans. Canonical signaling results in changes in gene expression, which is regulated by the nuclear effector of the pathway CSL (CBF1/RBP-J, Su(H), Lag-1). CSL is a DNA binding protein that functions as either a repressor or an activator of transcription, depending upon whether it is complexed by transcriptional corepressor or coactivator proteins, respectively. In stark contrast to CSL… CONTINUE READING
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