Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

@article{Jacob2007TranscriptionalRC,
  title={Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis},
  author={J. Jacob and Anna L. M. Ferri and Christopher Milton and Fabrice Prin and Patrick Pla and Wei Ju Lin and Anthony Gavalas and S Ang and James Briscoe},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={1433-1439}
}
In many regions of the developing CNS, distinct cell types are born at different times. The means by which discrete and stereotyped temporal switches in cellular identities are acquired remains poorly understood. To address this, we have examined how visceral motor neurons (VMNs) and serotonergic neurons, two neuronal subtypes, are sequentially generated from a common progenitor pool in the vertebrate hindbrain. We found that the forkhead transcription factor Foxa2, acting in progenitors, is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Subset specification of central serotonergic neurons

Front. Cell. Neurosci. • 2013
View 4 Excerpts
Highly Influenced

Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 10 Excerpts
Highly Influenced

Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2014
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 56 references

multiple cells, multiple signals

M. Placzek, Briscoe, J. The floor plate
Nat. Rev. Neurosci. 6, 230–240 • 2005

Similar Papers

Loading similar papers…