Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors.

@article{Leichter1999TranscriptionalRB,
  title={Transcriptional repression by the zinc finger protein REST is mediated by titratable nuclear factors.},
  author={Michael Leichter and Gerald Thiel},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 6},
  pages={
          1937-46
        }
}
The zinc finger protein REST (RE-1 silencing transcription factor) is a transcriptional repressor that inhibits neuronal gene transcription in non-neuronal tissues. REST may represent a master regulator of neuronal gene expression. REST contains two repressor domains located at the N- and C-termini of the molecule. To investigate the molecular mechanism of transcriptional repression by REST, in vivo competition experiments were performed. Both repression domains were expressed in the nucleus as… CONTINUE READING
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