Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

  title={Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex},
  author={Xinsheng Nan and H. Ng and C. Johnson and Carol D. Laherty and B. Turner and R. Eisenman and A. Bird},
  • Xinsheng Nan, H. Ng, +4 authors A. Bird
  • Published 1998
  • Biology, Medicine
  • Nature
  • Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term silencing of certain genes during mammalian development, and in repression of viral genomes,. The methyl-CpG-binding proteins MeCP1 (ref. 5) and MeCP2 (ref. 6) interact specifically with methylated DNA and mediate transcriptional repression. Here we study the mechanism of repression by MeCP2, an abundant nuclear protein that is essential… CONTINUE READING
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