Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.

Abstract

RVR/Rev-erb beta/BD73 is an orphan steroid receptor that has no known ligand in the "classical' sense. RVR binds as a monomer to an element which consists of an A/T-rich sequence upstream of the consensus hexameric half-site. However, RVR does not activate transcription and blocks transactivation of this element by ROR/RZR. The mechanism of RVR action… (More)

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@article{Burke1996TranscriptionalRB, title={Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: functional evidence for a biological role of RVR in myogenesis.}, author={Les J Burke and Meredith Downes and Amanda J. Carozzi and Vincent Gigu{\`e}re and George E. O. Muscat}, journal={Nucleic acids research}, year={1996}, volume={24 18}, pages={3481-9} }