Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein

  title={Transcriptional repression by YY1, a human GLI-Kr{\"u}ippel-related protein, and relief of repression by adenovirus E1A protein},
  author={Y. Shi and E. Seto and Long-Sheng Chang and T. Shenk},
  • Y. Shi, E. Seto, +1 author T. Shenk
  • Published 1991
  • Biology, Medicine
  • Cell
  • A sequence within the transcription control region of the adeno-associated virus P5 promoter has been shown to mediate transcriptional activation by the adenovirus E1A protein. We report here that this same element mediates transcriptional repression in the absence of E1A. Two cellular proteins have been found to bind to overlapping regions within this sequence element. One of these proteins, YY1, is responsible for the repression. E1A relieves repression exerted by YY1 and further activates… CONTINUE READING
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