Transcriptional repression by Tup1-Ssn6.

  title={Transcriptional repression by Tup1-Ssn6.},
  author={Tania M Malav{\'e} and Sharon Y.R Dent},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={84 4},
The Tup1-Ssn6 complex from budding yeast is one of the best studied corepressors and has served as a model for the study of similar corepressor complexes in higher eukaryotes. Tup1-Ssn6 represses multiple subsets of genes when recruited to promoters by sequence-specific DNA binding repressors. Tup1-Ssn6 mediated repression involves interactions among the corepressor and hypoacetylated histones, histone deacetylases, and the RNA transcriptional machinery. Nucleosome positioning is also involved… CONTINUE READING

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