Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes

@article{Huang1999TranscriptionalRB,
  title={Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes},
  author={Yunfei Huang and Scott J. Myers and Raymond J. Dingledine},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={867-872}
}
Many genes whose expression is restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription factor REST (also named NRSF or XBR). Although two independent domains of REST are known to confer repression, the mechanisms of transcriptional repression by REST remain obscure. We provide multiple lines of evidence that the N-terminal domain of REST represses transcription of the GluR2 and type II sodium-channel… CONTINUE READING
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A role for histone deacetylase activity in HDAC 1mediated transcriptional repression

  • C. A. Hassig
  • Proc . Natl . Acad . Sci . USA
  • 1998

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