Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.

@article{Malik2001TranscriptionalRA,
  title={Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.},
  author={T. H. Malik and Sarah A. Shoichet and Peter Latham and Todd G. Kroll and Luanne Laurel Peters and Ramesh A. Shivdasani},
  journal={The EMBO journal},
  year={2001},
  volume={20 7},
  pages={1715-25}
}
Known vertebrate GATA proteins contain two zinc fingers and are required in development, whereas invertebrates express a class of essential proteins containing one GATA-type zinc finger. We isolated the gene encoding TRPS1, a vertebrate protein with a single GATA-type zinc finger. TRPS1 is highly conserved between Xenopus and mammals, and the human gene is implicated in dominantly inherited tricho-rhino-phalangeal (TRP) syndromes. TRPS1 is a nuclear protein that binds GATA sequences but fails… CONTINUE READING