Transcriptional regulatory networks in bacteria: from input signals to output responses.

@article{Seshasayee2006TranscriptionalRN,
  title={Transcriptional regulatory networks in bacteria: from input signals to output responses.},
  author={Aswin Seshasayee and Paul Bertone and Gillian M. Fraser and Nicholas M. Luscombe},
  journal={Current opinion in microbiology},
  year={2006},
  volume={9 5},
  pages={
          511-9
        }
}
Transcriptional regulatory systems play a central role in coordinating bacterial responses to diverse stimuli. These systems can be studied in progressive stages: from input signals to the final output. At the input stage, transcription factors (TFs) can be classified by their activation from endogenous or exogenous stimuli; in Escherichia coli, up to three-quarters of regulators are estimated to respond directly to extracellular signals through phosphorylation and small-molecule binding. At… CONTINUE READING
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