Transcriptional regulatory elements in the human genome.

@article{Maston2006TranscriptionalRE,
  title={Transcriptional regulatory elements in the human genome.},
  author={Glenn A. Maston and S. Evans and M. R. Green},
  journal={Annual review of genomics and human genetics},
  year={2006},
  volume={7},
  pages={
          29-59
        }
}
The faithful execution of biological processes requires a precise and carefully orchestrated set of steps that depend on the proper spatial and temporal expression of genes. Here we review the various classes of transcriptional regulatory elements (core promoters, proximal promoters, distal enhancers, silencers, insulators/boundary elements, and locus control regions) and the molecular machinery (general transcription factors, activators, and coactivators) that interacts with the regulatory… Expand
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