Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes

@article{Kim2000TranscriptionalRE,
  title={Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes},
  author={Kyoung-Eun Kim and Chunyan Gu and Sanjay Thakur and Eric Vieira and Jennifer C Lin and Arnold B. Rabson},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={1334-1345}
}
C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas. The contribution of these alterations to lymphomagenesis is not understood; however, truncation at amino acid 666 to generate 80–85 kD proteins in the HUT78 cell line is associated with addition of a short (serine-alanine-serine) fusion at the 3′ end of p80HT, as well as with increased expression of NFKB2 mRNA. We… CONTINUE READING

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