Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection.

@article{Staib2002TranscriptionalRC,
  title={Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection.},
  author={Peter Staib and Marianne Kretschmar and Thomas Nichterlein and Herbert Hof and Joachim Morschh{\"a}user},
  journal={Infection and immunity},
  year={2002},
  volume={70 2},
  pages={921-7}
}
The opportunistic fungal pathogen Candida albicans can cause superficial as well as systemic infections. Successful adaptation to the different host niches encountered during infection requires coordinated expression of various virulence traits, including the switch between yeast and hyphal growth forms and secretion of aspartic proteinases. Using an in vivo expression technology that is based on genetic recombination as a reporter of gene activation during experimental candidiasis in mice, we… CONTINUE READING