Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter.

Abstract

Immune responses to invading pathogens are mediated largely through a family of transmembrane Toll-like receptors and modulated by a number of downstream effectors. In particular, a family of four interleukin 1 receptor-associated kinases (IRAK) regulates responsiveness to bacterial endotoxins. Pharmacological targeting of particular IRAK components may be… (More)

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