Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.

@article{Cohen2009TranscriptionalRO,
  title={Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.},
  author={Batya Cohen and Yoseph Addadi and Stav Sapoznik and Gila Meir and Vyacheslav Kalchenko and Alon Harmelin and Shifra Ben-Dor and Michal Neeman},
  journal={Neoplasia},
  year={2009},
  volume={11 9},
  pages={921-33}
}
Vascular endothelial growth factor C (VEGF-C) plays a critical role in tumor lymphangiogenesis and lymph node metastasis. We report here that VEGF-C expression is regulated by microenvironmental stress including hyperthermia and oxidative stress. Furthermore, we show that this stress response is mediated by transcriptional activation mediated by lens… CONTINUE READING