Transcriptional regulation of type I diabetes by NF-kappa B.

  title={Transcriptional regulation of type I diabetes by NF-kappa B.},
  author={Salah-Eddine Lamhamedi-Cherradi and Shijun Zheng and Brendan Hilliard and Lingyun Xu and Jing Sun and Saaib Alsheadat and Hsiou-chi Liou and Youhai H Chen},
  journal={Journal of immunology},
  volume={171 9},
Development of type I diabetes requires coordinated expression of myriad genes responsible for the initiation and progression of the disease. Expression of these genes are regulated by a small number of transcription factors including the Rel/NF-kappaB family. To determine the roles of the Rel/NF-kappaB family in type I diabetes, we studied multiple low-dose streptozotocin-induced diabetes in mice deficient in either c-Rel or NF-kappaB1. We found that mice deficient in each of these NF-kappaB… CONTINUE READING


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