Transcriptional regulation of epithelial-mesenchymal transition.

  title={Transcriptional regulation of epithelial-mesenchymal transition.},
  author={Yingqi Teng and Michael Zeisberg and Raghu Kalluri},
  journal={The Journal of clinical investigation},
  volume={117 2},
It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such distinct signaling pathways orchestrate the complex cellular events that facilitate EMT is not well… CONTINUE READING

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