Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein.

@article{KingsleyKallesen1999TranscriptionalRO,
  title={Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein.},
  author={Michelle L Kingsley-Kallesen and Daina Kelly and Angie Rizzino},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 48},
  pages={
          34020-8
        }
}
Transcription of the transforming growth factor-beta2 (TGF-beta2) gene is dependent on a cAMP-response element/activating transcription factor (CRE/ATF) site that is bound by CREB and ATF-1 as well as an E-box motif that is bound by upstream stimulatory factors 1 and 2 (USF1 and USF2). To identify additional factors involved in the expression of the TGF-beta2 gene, we employed F9 embryonal carcinoma (EC) cells, which express TGF-beta2 only after the cells differentiate. We show that… CONTINUE READING
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Transcriptional Regulation of the TGF-b2 Gene

  • D. Kelly, S. J. Kim, A. Rizzino
  • J. Biol. Chem. 273,
  • 1998
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