Transcriptional regulation of the pendrin gene.

  title={Transcriptional regulation of the pendrin gene.},
  author={Julia Rozenfeld and Edna Efrati and Lior Adler and Osnat Tal and Stephen L Carrithers and Seth L Alper and Israel Zelikovic},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={28 3},
Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively. The molecular mechanisms controlling pendrin activity in renal, thyroid and inner ear epithelia have been the subject of recent studies. The effects of ambient pH, the hormone aldosterone and the peptide uroguanylin (UGN; the "intestinal… CONTINUE READING
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