Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.

@article{Linhares2004TranscriptionalRO,
  title={Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.},
  author={Vania L F Linhares and Norma Aparecida dos Santos Almeida and Diego C Menezes and David A Elliott and Donna Lai and Eric C Beyer and Ant{\^o}nio Carlos Campos De Carvalho and Mauro W. Costa},
  journal={Cardiovascular research},
  year={2004},
  volume={64 3},
  pages={402-11}
}
OBJECTIVE Connexin40 (Cx40) is a gap junction protein expressed specifically in developing and mature atrial myocytes and cells of the conduction system. In this report, we identify cis-acting elements within the mouse Cx40 promoter and unravel part of the complex pathways involved in the cardiac expression of this gene. METHODS To identify the factors involved in the cardiac expression of Cx40, we used transient transfections in mammalian cells coupled with electrophoretic mobility shift… CONTINUE READING

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