Transcriptional regulation of the human neutral ceramidase gene.


Ceramidases play a critical role in generating sphingosine-1-phosphate by hydrolyzing ceramide into sphingosine, a substrate for sphingosine kinase. In order to elucidate its transcriptional regulation, we identify here a putative promoter region in the 5'-UTR of the human neutral CDase (nCDase) gene. Using human genomic DNA, we cloned a 3000 bp region… (More)
DOI: 10.1016/


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@article{ONeill2011TranscriptionalRO, title={Transcriptional regulation of the human neutral ceramidase gene.}, author={Sean M O'Neill and Jong K. Yun and Todd E. Fox and Mark Kester}, journal={Archives of biochemistry and biophysics}, year={2011}, volume={511 1-2}, pages={21-30} }