Transcriptional regulation of the human NA/K ATPase via the human mineralocorticoid receptor

@article{Kolla2000TranscriptionalRO,
  title={Transcriptional regulation of the human NA/K ATPase via the human mineralocorticoid receptor},
  author={Venkatadri Kolla and Gerald Litwack},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={204},
  pages={35-40}
}
The mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) are members of the steroid/thyroid hormone receptor superfamily of ligand inducible transcription factors and have been shown to bind the glucocorticoid response element (GRE). Sodium-potassium ATPase (Na/K ATPase) is a major target of mineralocorticoids. Both aldosterone and glucocorticoids activate the human Na/K ATPase α1 subunit and β1 subunit genes transcriptionally. However, the mechanisms of corticosteroid… CONTINUE READING
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