Transcriptional regulation of the epiregulin gene in the rat ovary.

@article{Sekiguchi2002TranscriptionalRO,
  title={Transcriptional regulation of the epiregulin gene in the rat ovary.},
  author={Toshio Sekiguchi and Tetsuya Mizutani and Kazuya Yamada and Takashi Osaka Yazawa and Hiroko Kawata and Miki Yoshino and Takashi Kajitani and Takashi Kameda and Takashi Minegishi and Kaoru Miyamoto},
  journal={Endocrinology},
  year={2002},
  volume={143 12},
  pages={
          4718-29
        }
}
Ovarian follicular development is initiated by FSH secreted from the pituitary gland. The FSH-induced follicular development involves granulosa cell proliferation and differentiation. We demonstrated that a growth factor of epidermal growth factor (EGF) family epiregulin was rapidly induced in the primary culture of rat ovarian granulosa cells by FSH within 1 h. Epiregulin gene expression was also observed in granulosa cells of antral ovarian follicles from pregnant mare's serum gonadotropin… CONTINUE READING

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