Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

Abstract

Inappropriate expression of proinflammatory mediators underpins the pathogenesis of autoimmune disease and tumor metastasis. The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via activation of TLR4. Little tenascin-C is observed in most healthy adult tissues… (More)
DOI: 10.4049/jimmunol.0903359

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@article{Goh2010TranscriptionalRO, title={Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.}, author={Fui G Goh and Anna Maria Piccinini and Thomas Krausgruber and Irina A Udalova and Kim S. Midwood}, journal={Journal of immunology}, year={2010}, volume={184 5}, pages={2655-62} }