Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells

@article{Ouellet2006TranscriptionalRO,
  title={Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells},
  author={St{\'e}phane Ouellet and François Vigneault and Maryse Lessard and Steeve Leclerc and R N Kathy Drouin and Sylvain L. Gu{\'e}rin},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={6472 - 6487}
}
The cyclin-dependent kinase inhibitor 1A (CDKN1A), also known as p21 (WAF1/CIP1) modulates cell cycle, apoptosis, senescence and differentiation via specific protein-protein interactions with the cyclins, cyclin-dependent kinase (Cdk), and many others. Expression of the p21 gene is mainly regulated at the transcriptional level. By conducting both ligation-mediated PCR (LMPCR) and chromatin immunoprecipitation (ChIP) in vivo, we identified a functional target site for the transcription factor… CONTINUE READING

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