Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix.

@article{Bissell1990TranscriptionalRO,
  title={Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix.},
  author={Daniel M. Bissell and Joan McIntyre Caron and Lee E. Babiss and Joshua M. Friedman},
  journal={Molecular biology & medicine},
  year={1990},
  volume={7 2},
  pages={187-97}
}
The expression of tissue-specific functions by hepatocytes in primary culture is enhanced in the presence of an extracellular matrix. A basement membrane-like substratum, derived from the Engelbreth-Holm-Swarm mouse sarcoma (EHS) and termed EHS gel, supports synthesis and secretion of albumin for at least three weeks, in contrast to a conventional substratum (plastic or collagen-coated plastic), on which cells rapidly lose this function. The presence of an EHS matrix (as a substratum or added… CONTINUE READING

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