Transcriptional regulation of the Th17 immune response by IKKα

  title={Transcriptional regulation of the Th17 immune response by IKKα},
  author={Li Li and Qingguo Ruan and Brendan Hilliard and Jennifer DeVirgiliis and Michael Karin and Youhai H Chen},
  booktitle={The Journal of experimental medicine},
Th17 cells are a subset of T cells that play crucial roles in the pathogenesis of many inflammatory diseases. We report here the identification of IKKα (inhibitor of NF-κB kinase-α) as a key transcriptional regulator of the Th17 lineage. T cells expressing a nonactivatable form of IKKα were significantly compromised in their ability to produce IL-17 and to initiate neural inflammation. IKKα is present in the nuclei of resting CD4(+) T cells. Upon Th17 differentiation, IKKα selectively… CONTINUE READING
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IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2015
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